Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult
Objective: Mitochondrial pyruvate is a critical intermediary metabolite in gluconeogenesis, lipogenesis, and NADH production.As a result, the mitochondrial pyruvate copyright (MPC) complex has emerged as a promising therapeutic target in metabolic diseases.Clinical trials are currently underway.However, recent in vitro data indicate that MPC inhibi